rTraumatic experiences “biologically embed” themselves in select genes, subsequently alter their functions and lead to the development of post-traumatic stress disorder (PTSD), a study has revealed. Conducted by researchers at Columbia University’s Mailman School of Public Health, the study is the first large scale investigation to search for trauma-induced changes in the genes of people with PTSD. “Our findings suggest a new biological model of PTSD in which alteration of genes, induced by a traumatic event, changes a person’s stress response and leads to the disorder,” said Dr. Sandro Galea, principal investigator of the study. “Identification of the biologic underpinnings of PTSD will be crucial for developing appropriate psychological and/or pharmacological interventions, particularly in the wake of an increasing number of military veterans returning home following recent wars worldwide,” he added. Previous studies have found that lifetime experiences may alter the activity of specific genes by changing their methylation patterns. Methylated genes are generally inactive, while unmethylated genes are generally active. In the new study, DNA samples were obtained from participants in the Detroit Neighborhood Health Study (DNHS), a longitudinal epidemiologic study investigating PTSD and other mental disorders in the city of Detroit. The researchers analyzed the methylation patterns of over 14,000 genes from blood samples taken from 100 Detroit residents, 23 of whom suffer from PTSD. The analysis found that participants with PTSD had six to seven times more unmethylated genes than unaffected participants, and most of the unmethylated genes were involved in the immune system. The observed methylation changes in the immune system genes were reflected in the PTSD participants’ immune systems levels of antibodies to a herpes virus were high in PTSD patients, indicative of a compromised immune system. While people who experience severe trauma will exhibit a normal stress response, in PTSD, the stress response system becomes deregulated and chronically overactive causing compromised immune functioning. PTSD has long been linked to increased risk of numerous physical health problems – including diabetes and cardiovascular disease. The study suggests why PTSD is so strongly associated with physical health problems – trauma exposure causes epigenetic changes in immune system genes and thus, compromised immune functioning putting individuals at risk for a host of disorders. “Our findings show that PTSD may be associated with epigenetic changes in immune-system genes. If this is the case, these clusters could provide clues to our understanding of how a traumatic event changes gene expression, thus altering immune function and resulting in other possible physiologic alterations,” said Galea. The findings are published online in Proceedings of the National Academy of Sciences (PNAS).